Allosteric Regulation of the Conformational Dynamics of a Cavitand Receptor

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• 作者：Zhiqing Yan ; Yuning Chang ; Dennis Mayo ; Veselin Maslak ; Shijing Xia ; Jovica D. Badji//pubs.acs.org/images/entities/cacute.gif" border="0">
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：August 17, 2006
• 年：2006
• 卷：8
• 期：17
• 页码：3697 - 3700
• 全文大小：164K
• 年卷期：v.8,no.17(August 17, 2006)
• ISSN：1523-7052

文摘

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Inspired by allostery in nature, we synthesized cavitand 1 and investigated regulation of its conformational dynamics. Quantitative ¹H NMRstudies have revealed that the rate of the conformational isomerization of 1 can be modulated using the external addition of acid. As 1maintains its vase-like conformation in an acidic environment, ample opportunities for controlling the kinetics of molecular recognition, andthus reactivity, in this and related receptors have arisen.