An Efficient Synthesis of Highly Functionalized [5,6] Aromatic Spiroketals by Hetero-Diels-Alder Reaction

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• 作者：Guanglian Zhou ; Jianrong Zhu ; Zhixiang Xie ; Ying Li
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 6, 2008
• 年：2008
• 卷：10
• 期：5
• 页码：721 - 724
• 全文大小：81K
• 年卷期：v.10,no.5(March 6, 2008)
• ISSN：1523-7052

文摘

A hetero-Diels-Alder reaction of vinyl sulfoxides with o-quinone methides precursor constructs highly functionalized [5,6] aromatic spiroketalskeletons in moderate to good yields with high regioselectivity. The two functional groups (ketone and olefin) can be further subjected tomany synthetic transformations.