文摘
Biodegradable and biocompatible poly(p-dioxanone)鈥損oly(tetramethylene oxide)glycol (PPDO鈥揚TMEG) multiblock copolymers with excellent shape memory effect and mechanical properties were developed by coupling PPDO-diol and PTMEG-diol with 1,6-hexamethylene diisocyanate (HDI). The influences of chain structure, microphase separating morphology on shape memory effect, and biocompatibility were investigated systematically. The TEM observation of PPDO鈥揚TMEG poly(ether-ester)-polyether exhibited the relationship between characteristic microphase separating morphology and shape memory effect. Interestingly, differential scanning calorimetry (DSC) analysis indicated that Tg,PPDO was close to Tc,PTMEG, which provided the possibility that the reversible phase combined PTMEG segments and the amorphous phase of PPDO segments. The synergistic effect ensured copolymers owning both high Rf and Rr (96.6% and 92.9% with PTMEG segments only 15% in weight fraction), as well as the mechanical properties when T > Ttrans. Moreover, biocompatible evaluation results showed that the cell adhesion and proliferation could be enhanced on copolymers with more PTMEG segments, indicating potential application in minimally invasive surgery.