N-Heterocyclic Carbene-Catalyzed Domino Ring-Opening/Redox Amidation/Cyclization Reactions of Formylcyclopropane 1,1-Diesters: Direct Construction of a 6−5−6 Tricyclic Hydropyrido[1,2-a

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• 作者：Ding Du ; Linxia Li ; Zhongwen Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：June 5, 2009
• 年：2009
• 卷：74
• 期：11
• 页码：4379-4382
• 全文大小：198K
• 年卷期：v.74,no.11(June 5, 2009)
• ISSN：1520-6904

文摘

Catalyzed by N-heterocyclic carbenes (NHCs), domino ring-opening/redox amidation/cyclization reactions of the readily available formylcyclopropane 1,1-diesters with 2-chloro-1H-indole-3-carboaldehydes were reported. This methodology provides an efficient and direct construction of a 6−5−6 tricyclic hydropyrido[1,2-a]indole skeleton, which can be potentially applied for the synthesis of several types of polycyclic indole alkaloids.