Synthesis, Insecticidal Activity, and QSAR of Novel Nitromethylene Neonicotinoids with Tetrahydropyridine Fixed cis Configuration and Exo-Ring Ether Modification

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• 作者：Zhongzhen Tian ; Xusheng Shao ; Zhong Li ; Xuhong Qian ; and ; Qingchun Huang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2007
• 出版时间：March 21, 2007
• 年：2007
• 卷：55
• 期：6
• 页码：2288 - 2292
• 全文大小：110K
• 年卷期：v.55,no.6(March 21, 2007)
• ISSN：1520-5118

文摘

To keep the nitro group in the cis position, a series of nitromethylene neonicotinoids containing atetrahydropyridine ring with exo-ring ether modifications were designed and synthesized. All of thecompounds were characterized and confirmed by ¹H NMR, high-resolution mass spectroscopy,elemental analysis, and IR. The bioassay tests showed that some of them exhibited good insecticidalactivities against pea aphids. On the basis of 10 nitromethylene derivatives, the quantitative structure-bioactivity relationship (QSAR) was analyzed and established. The results suggested that AlogP98and Dipole_Mopac might be the important parameters related with biological activities.