Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
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- 作者：Feng-Jiao Zhou ; Yin Nian ; Yongming Yan ; Ye Gong ; Qi Luo ; Yu Zhang ; Bo Hou ; Zhi-Li Zuo ; Shu-Mei Wang ; He-Hai Jiang ; Jian Yang ; Yong-Xian Cheng
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：June 19, 2015
- 年：2015
- 卷：17
- 期：12
- 页码：3082-3085
- 全文大小：258K
- ISSN：1523-7052
文摘
T-type calcium channel (TTCC) inhibitors hold great potential for the treatment of a variety of neurological disorders. Cochlearoids A鈥揈 (1鈥?b>5), five pairs of dimeric meroterpenoid enantiomers, and cochlearines A (6) and B (7), two pairs of enantiomeric hybrid metabolites, were isolated and characterized from Ganoderma cochlear. Biological evaluation found that compounds (+)-1, (鈭?-3, and (卤)-6 significantly inhibited Cav3.1 TTCC and showed noticeable selectivity against Cav1.2, Cav2.1, Cav2.2, and Kv11.1 (hERG) channels.