Ligand-Enabled Meta-C鈥揌 Alkylation and Arylation Using a Modified Norbornene
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- 作者：Peng-Xiang Shen ; Xiao-Chen Wang ; Peng Wang ; Ru-Yi Zhu ; Jin-Quan Yu
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：September 16, 2015
- 年：2015
- 卷：137
- 期：36
- 页码：11574-11577
- 全文大小：397K
- ISSN：1520-5126
文摘
2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp2)鈥揌 alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.