Rh(III)-Catalyzed Synthesis of Multisubstituted Isoquinoline and Pyridine N-Oxides from Oximes and Diazo Compounds

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• 作者：Zhuangzhi Shi ; Dennis C. Koester ; M茅lissa Boultadakis-Arapinis ; Frank Glorius
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：August 21, 2013
• 年：2013
• 卷：135
• 期：33
• 页码：12204-12207
• 全文大小：347K
• 年卷期：v.135,no.33(August 21, 2013)
• ISSN：1520-5126

文摘

Multisubstituted isoquinoline and pyridine N-oxides have been prepared by Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C鈥揌 activation. This intermolecular annulation involving tandem C鈥揌 activation, cyclization, and condensation steps proceeds under mild conditions, obviates the need for oxidants, releases N₂ and H₂O as the byproducts, and displays a broad substituent scope.