Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-hydroxypropyl-尾-cyclodextrin/Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent

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• 作者：Zhuxian Zhou ; Yawo Mondjinou ; Seok-Hee Hyun ; Aditya Kulkarni ; Zheng-Rong Lu ; David H. Thompson
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：October 14, 2015
• 年：2015
• 卷：7
• 期：40
• 页码：22272-22276
• 全文大小：328K
• ISSN：1944-8252

文摘

A multivalent magnetic resonance imaging agent based on a 2-hydroxypropyl-尾-cyclodextrin (HPCD):Pluronic F127 polyrotaxane carrier has been synthesized, and its blood pool contrast properties have been characterized. This Gd³⁺-DO3A-HPCD/Pluronic polyrotaxane construct is shown to circulate for more than 30 min and provide >100-fold vascular enhancement relative to the monomeric Gd³⁺-DO3A-HPCD control that is rapidly cleared via the kidney. The high r₁ relaxivity at 37 掳C (23.83 mM^鈥? s^鈥? at 1.5 T; 34.08 mM^鈥? s^鈥? at 0.5 T), extended blood circulation, well-known pharmacology of the polyrotaxane precursors, and absence of acute toxicity make it a highly attractive blood pool contrast agent candidate.