DNA Detection Using Plasmonic Enhanced Near-Infrared Photoluminescence of Gallium Arsenide

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• 作者：Longhua Tang ; Ik Su Chun ; Zidong Wang ; Jinghong Li ; Xiuling Li ; Yi Lu
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：October 15, 2013
• 年：2013
• 卷：85
• 期：20
• 页码：9522-9527
• 全文大小：267K
• 年卷期：v.85,no.20(October 15, 2013)
• ISSN：1520-6882

文摘

Efficient near-infrared detection of specific DNA with single nucleotide polymorphism selectivity is important for diagnostics and biomedical research. Herein, we report the use of gallium arsenide (GaAs) as a sensing platform for probing DNA immobilization and targeting DNA hybridization, resulting in 8-fold enhanced GaAs photoluminescence (PL) at 875 nm. The new signal amplification strategy, further coupled with the plasmonic effect of Au nanoparticles, is capable of detecting DNA molecules with a detection limit of 0.8 pM and selectivity against single base mismatches. Such an ultrasensitive near-infrared sensor can find a wide range of biochemical and biomedical applications.