Effect of Heparin on Viologen-Stimulated Enzymatic NADH Depletion

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• 作者：Jacek Zielonka ; Ma//pubs.acs.org/images/entities/lstrok.gif" border="0">gorzata Rybak ; Joanna Celi//pubs.acs.org/images/entities/nacute.gif" border="0">ska ; Jan Adamus ; A
• 刊名：Chemical Research in Toxicology
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：19
• 期：5
• 页码：668 - 673
• 全文大小：93K
• 年卷期：v.19,no.5(May 2006)
• ISSN：1520-5010

文摘

Paraquat and diquat undergo redox cycling mediated by xanthine oxidase in the NADH-dependentmanner. In these processes, the rates of NADH oxidation and superoxide formation are increased almost10-fold. The addition of heparin can substantially inhibit these processes. A protective role of heparinagainst oxygen radicals formation can be rationalized in terms of its ability to bind paraquat or diquat.The binding process has been investigated by means of the pulse radiolysis technique. Biologicalconsequences of the binding processes are discussed.