Pd(0)-Catalyzed Coupling-Cyclization of 2-(2',3'-Allenyl)acetylacetates and Organic Halides: An Efficient Synthesis of 4,5-Dihydrofuran Derivatives

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• 作者：Shengming Ma ; Zilong Zheng ; Xuefeng Jiang
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：February 1, 2007
• 年：2007
• 卷：9
• 期：3
• 页码：529 - 531
• 全文大小：62K
• 年卷期：v.9,no.3(February 1, 2007)
• ISSN：1523-7052

文摘

Highly chemo- and regioselective Pd(0)-catalyzed coupling-cyclization of 2-(2',3'-allenyl)acetylacetates with organic halides using K₃PO₄ asbase in DMF efficiently afforded 4,5-dihydrofuran derivatives in moderate to excellent yields, with a selectivity of >97:3.