Biodegradable Nanoparticles Based on Linoleic Acid and Poly(β-malic acid) Double Grafted Chitosan Derivatives as Carriers of Anticancer Drugs
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- 作者：Ziming Zhao† ; ‡ ; ; Miao He† ; ‡ ; ; Lichen Yin† ; ; Jiamin Bao‡ ; ; Lili Shi† ; ‡ ;
- 刊名：Biomacromolecules
- 出版年：2009
- 出版时间：March 9, 2009
- 年：2009
- 卷：10
- 期：3
- 页码：565-572
- 全文大小：251K
- 年卷期：v.10,no.3(March 9, 2009)
- ISSN：1526-4602
文摘
Novel chitosan derivatives carrying linoleic acid (LA) as hydrophobic moieties and poly(β-malic acid) (PMLA) as hydrophilic moieties (LA/PMLA double grafted chitosan, LMC) were synthesized. It self-assembled into nanoparticles of 190−350 nm in water, which carried negative surface charges in physiological pH. The critical aggregation concentration of the LMC deceased with an increase in the LA content. Paclitaxel (PTX) was loaded into the LMC nanoparticles with a high loading efficiency and the maximum loading capacity of 9.9 ± 0.4%. PTX−LMC nanoparticles exhibited a sustained release within 24 h in pH 7.4 phosphate-buffered saline (PBS), and the release rate was affected by the LA content and PMLA length. Hemolysis and acute toxicity assessment indicated that the LMC nanoparticles were safe drug carriers for i.v. administration. Additionally, PTX−LMC showed significantly potent tumor inhibition efficacy relative to that of TAXOL in S-180 bearing mice. Therefore, the LMC nanoparticles could be an effective and safe vehicle for systemic administration of hydrophobic drugs, especially PTX.