Emerging Techniques in Proteomics for Probing Nano鈥揃io Interactions

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• 作者：Zon W. Lai ; Yan Yan ; Frank Caruso ; Edouard C. Nice
• 刊名：ACS Nano
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：6
• 期：12
• 页码：10438-10448
• 全文大小：606K
• 年卷期：v.6,no.12(December 21, 2012)
• ISSN：1936-086X

文摘

Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities for improved lesion-specific therapy. Understanding and controlling the nano鈥揵io interactions of these materials is central to future developments in this area. Mass-spectrometry-based proteomics techniques, in conjunction with other emerging technologies, are enabling novel insights into the modulation of particle surfaces by biological fluids (formation of the protein corona) and subsequent particle-induced cellular responses. In this Perspective, we summarize important recent developments using proteomics-based techniques to understand nano鈥揵io interactions and discuss the impact of such knowledge on improving particle design.