Synthesis of -Lactams from a N-Rhenaimine: Effect of the Transition Metal on the Energetic Profile of the Stau
详细信息 查看全文
- 作者：Eva Hevia ; Julio Pé ; rez ; Ví ; ctor Riera ; Daniel Miguel ; Pablo Campomanes ; M. Isabel Mené ; ndez ; Tomá ; s L. Sordo ; and Santiago Garcí ; a-Granda
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：April 2, 2003
- 年：2003
- 卷：125
- 期：13
- 页码：3706 - 3707
- 全文大小：50K
- 年卷期：v.125,no.13(April 2, 2003)
- ISSN：1520-5126
文摘
As depicted in the scheme, the alkylidenamido complex 1, a N-rhenaimine, reacts with ketenes to afford the 
-lactams 2-4, which possess a {Re(CO)3(bpy)} fragment as substituent at nitrogen. Clean demetalations using HOTf or MeOTf yield the free -lactams or N-methyl--lactams along with [Re(OTf)(CO)3(bpy)]. DFT calculations help to rationalize why the reaction is faster than those of non transition metal N-substituted imines.
-lactams 2-4, which possess a {Re(CO)3(bpy)} fragment as substituent at nitrogen. Clean demetalations using HOTf or MeOTf yield the free -lactams or N-methyl--lactams along with [Re(OTf)(CO)3(bpy)]. DFT calculations help to rationalize why the reaction is faster than those of non transition metal N-substituted imines.