Dendrimers: Novel Polymeric Nanoarchitectures for Solubility Enhancement
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- 作者：Umesh Gupta ; Hrushikesh Bharat Agashe ; Abhay Asthana ; and N. K. Jain
- 刊名：Biomacromolecules
- 出版年：2006
- 出版时间：March 2006
- 年：2006
- 卷：7
- 期：3
- 页码：649 - 658
- 全文大小：311K
- 年卷期：v.7,no.3(March 2006)
- ISSN：1526-4602
文摘
Poor solubility and hydrophobicity of drugs/bioactives limit their possible applications in drug delivery andformulation development. Apart from conventional methods of solubility enhancement, there are some novelmethods which can be used in solubilization. Dendrimers represent a novel type of polymeric material that hasgenerated much interest in many diverse areas due to their unique structure and properties. Dendrimer-mediatedsolubility enhancement mainly depends on factors such as generation size, dendrimer concentration, pH, core,temperature, and terminal functionality. Added advantage in solubilization can be achieved considering thesefactors. Available literature suggests that ionic interaction, hydrogen bonding, and hydrophobic interactions arethe possible mechanisms by which a dendrimer exerts its solubilizing property. This review presents variousmechanisms and reports relating to solubility enhancement using dendrimers. Also, micellar behavior and futurepossibilities in relation to solubilization via dendrimers are included.