Nickel-Catalyzed C–H Alkynylation of Anilines: Expedient Access to Functionalized Indoles and Purine Nucleobases

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• 作者：Zhixiong Ruan ; Sebastian Lackner ; Lutz Ackermann
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：6
• 期：7
• 页码：4690-4693
• 全文大小：425K
• 年卷期：0
• ISSN：2155-5435

文摘

C–H alkynylations of electron-rich anilines were accomplished by means of user-friendly nickel catalysis. The C–H functionalization occurred with high positional selectivity and ample scope by kinetically relevant C–H activation. The robust nickel catalyst tolerated synthetically useful functional groups, which set the stage for the facile synthesis of substituted indoles. The chemoselectivity of the cost-effective nickel catalyst was reflected by enabling transformative nickel-catalyzed C–H functionalization with purine nucleobases through monodentate chelation assistance.