Development and Scale-up of a Biocatalytic Process To Form a Chiral Sulfoxide
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- 作者：William R. F. GoundryBradley Adams ; Helen Benson ; Julie Demeritt ; Steven McKown ; Keith Mulholland ; Amy Robertson ; Paul Siedlecki ; Paula Tomlin ; Kevin Vare
- 刊名：Organic Process Research & Development
- 出版年：2017
- 出版时间：January 20, 2017
- 年：2017
- 卷：21
- 期：1
- 页码：107-113
- 全文大小：353K
- ISSN：1520-586X
文摘
A Baeyer–Villiger monooxygenase enzyme has been used to manufacture a chiral sulfoxide drug intermediate on a kilogram scale. This paper describes the evolution of the biocatalytic manufacturing process from the initial enzyme screen, development of a kilo lab process, to further optimization for plant scale manufacture. Efficient gas–liquid mass transfer of oxygen is key to obtaining a high yield.