Inhibitory Effect of Macabarterin, a Polyoxygenated Ellagitannin from Macaranga barteri, on Human Neutrophil Respiratory Burst Activity

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• 作者：Rostand Manfouo Ngoumfo ; Georges Eric Ngounou ; Chimene Victoire Tchamadeu ; Muhammad Irfan Qadir ; Celine Djama Mbazoa ; Afshan Begum ; Fernande Ngounou Ngninzeko ; David Lontsi ; Muhammad Iqbal Choudhary
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：December 1, 2008
• 年：2008
• 卷：71
• 期：11
• 页码：1906-1910
• 全文大小：148K
• 年卷期：v.71,no.11(December 1, 2008)
• ISSN：1520-6025

文摘

An ellagitannin with a 2,4-acyl group, named macabarterin (1), and a new ellagic acid glycoside, 3-O-methylellagic acid 4-O-β-d-xylopyranoside (2), were isolated from the stem bark extract of Macaranga barteri along with five known phenolic compounds, ellagic acid (3), 3-O-methylellagic acid (4), gallic acid (5), methyl gallate (6), and scopoletin (7). The structures of 1 and 2, as well as those of the known compounds, were elucidated on the basis of spectroscopic data and by comparison with reported data. Compounds 1−5 and 7 were tested for their anti-inflammatory potential in a cell-based respiratory burst assay, compound 1 being found an inhibitor of the superoxides produced in the cellular system.