Cyclocurcumin, an Antivasoconstrictive Constituent of Curcuma longa (Turmeric)
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- 作者：Keunyoung Kim ; Jung-Jun Kim ; Yeryeon Jung ; Ji-Yoon Noh ; Ahmed Shah Syed ; Chul Young Kim ; Moo-Yeol Lee ; Kyung-Min Lim ; Ok-Nam Bae ; Jin-Ho Chung
- 刊名：Journal of Natural Products
- 出版年：2017
- 出版时间：January 27, 2017
- 年：2017
- 卷：80
- 期：1
- 页码：196-200
- 全文大小：378K
- ISSN：1520-6025
文摘
Despite the increasing attention on the therapeutic potential of <i>Curcuma longai> (turmeric), the biological activities of curcuminoids other than curcumin are not well understood. Here, we investigated antivasoconstrictive activities of <i>C. longai> extract and its ingredients using freshly isolated rat aortic rings. <i>C. longai> extract significantly suppressed agonist-stimulated vasoconstriction, and cyclocurcumin was found to be the most potent (IC50 against phenylephrine-induced vasoconstriction: 14.9 ± 1.0 μM) among the 10 tested ingredients including four curcuminoids. Cyclocurcumin significantly inhibited contraction of vascular smooth muscle, which was mediated by the suppression of myosin-light-chain phosphorylation and calcium influx via the L-type calcium channel. The inhibitory effect of cyclocurcumin was observed to be reversible and without cytotoxicity. Taken together, we demonstrated that cyclocurcumin, a bioactive ingredient in <i>C. longai>, may have a therapeutic potential as a novel antivasoconstrictive natural product.