Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Alkyl Bromides: Et3N as the Terminal Reductant

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• 作者：Zhengli Duan ; Wu Li ; Aiwen Lei
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：18
• 期：16
• 页码：4012-4015
• 全文大小：366K
• 年卷期：0
• ISSN：1523-7052

文摘

Reductive cross-coupling has emerged as a direct method for the construction of carbon–carbon bonds. Most cobalt-, nickel-, and palladium-catalyzed reductive cross-coupling reactions to date are limited to stoichiometric Mn(0) or Zn(0) as the reductant. One nickel-catalyzed cross-coupling paradigm using Et₃N as the terminal reductant is reported. By using this photoredox catalysis and nickel catalysis approach, a direct Csp²–Csp³ reductive cross-coupling of aryl bromides with alkyl bromides is achieved under mild conditions without stoichiometric metal reductants.