Silver(I)-Promoted Conversion of Thioamides to Amidines: Divergent Synthesis of a Key Series of Vancomycin Aglycon Residue 4 Amidines That Clarify Binding Behavior to Model Ligands
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- 作者：Akinori Okano ; Robert C. James ; Joshua G. Pierce ; Jian Xie ; Dale L. Boger
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：May 30, 2012
- 年：2012
- 卷：134
- 期：21
- 页码：8790-8793
- 全文大小：320K
- 年卷期：v.134,no.21(May 30, 2012)
- ISSN：1520-5126
文摘
Development of a general Ag(I)-promoted reaction for the conversion of thioamides to amidines is disclosed. This reaction was employed to prepare a key series of vancomycin aglycon residue 4 substituted amidines that were used to clarify their interaction with model ligands of peptidoglycan precursors and explore their resulting impact on antimicrobial properties.