Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
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- 作者：Atsushi Nakayama ; Akinori Okano ; Yiqing Feng ; James C. Collins ; Karen C. Collins ; Christopher T. Walsh ; Dale L. Boger
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：July 3, 2014
- 年：2014
- 卷：16
- 期：13
- 页码：3572-3575
- 全文大小：276K
- ISSN：1523-7052
文摘
Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.