Multimodal Polymer Nanoparticles with Combined 19F Magnetic Resonance and Optical Detection for Tunable, Targeted, Multimodal Imaging in Vivo

详细信息    查看全文

• 作者：Barbara E. Rolfe ; Idriss Blakey ; Oliver Squires ; Hui Peng ; Nathan R. B. Boase ; Cameron Alexander ; Peter G. Parsons ; Glen M. Boyle ; Andrew K. Whittaker ; Kristofer J. Thurecht
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：February 12, 2014
• 年：2014
• 卷：136
• 期：6
• 页码：2413-2419
• 全文大小：450K
• ISSN：1520-5126

文摘

Understanding the complex nature of diseased tissue in vivo requires development of more advanced nanomedicines, where synthesis of multifunctional polymers combines imaging multimodality with a biocompatible, tunable, and functional nanomaterial carrier. Here we describe the development of polymeric nanoparticles for multimodal imaging of disease states in vivo. The nanoparticle design utilizes the abundant functionality and tunable physicochemical properties of synthetically robust polymeric systems to facilitate targeted imaging of tumors in mice. For the first time, high-resolution ¹⁹F/¹H magnetic resonance imaging is combined with sensitive and versatile fluorescence imaging in a polymeric material for in vivo detection of tumors. We highlight how control over the chemistry during synthesis allows manipulation of nanoparticle size and function and can lead to very high targeting efficiency to B16 melanoma cells, both in vitro and in vivo. Importantly, the combination of imaging modalities within a polymeric nanoparticle provides information on the tumor mass across various size scales in vivo, from millimeters down to tens of micrometers.