Iron(III)-Doped, Silica Nanoshells: A Biodegradable Form of Silica

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• 作者：Kristina K. Pohaku Mitchell ; Alexander Liberman ; Andrew C. Kummel ; William C. Trogler
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：August 29, 2012
• 年：2012
• 卷：134
• 期：34
• 页码：13997-14003
• 全文大小：435K
• 年卷期：v.134,no.34(August 29, 2012)
• ISSN：1520-5126

文摘

Silica nanoparticles are being investigated for a number of medical applications; however, their use in vivo has been questioned because of the potential for bioaccumulation. To obviate this problem, silica nanoshells were tested for enhanced biodegradability by doping iron(III) into the nanoshells. Exposure of the doped silica to small molecule chelators and mammalian serum was explored to test whether the removal of iron(III) from the silica nanoshell structure would facilitate its degradation. Iron chelators, such as EDTA, desferrioxamine, and deferiprone, were found to cause the nanoshells to degrade on the removal of iron(III) within several days at 80 掳C. When the iron(III)-doped, silica nanoshells were submerged in fetal bovine and human serums at physiological temperature, they also degrade via removal of the iron by serum proteins, such as transferrin, over a period of several weeks.