Alteration of Membrane Compositional Asymmetry by LiCoO2 Nanosheets

详细信息    查看全文

• 作者：Merve Do臒ang眉n ; Mimi N. Hang ; Julianne M. Troiano ; Alicia C. McGeachy ; Eric S. Melby ; Joel A. Pedersen ; Robert J. Hamers ; Franz M. Geiger
• 刊名：ACS Nano
• 出版年：2015
• 出版时间：September 22, 2015
• 年：2015
• 卷：9
• 期：9
• 页码：8755-8765
• 全文大小：725K
• ISSN：1936-086X

文摘

Given the projected massive presence of redox-active nanomaterials in the next generation of consumer electronics and electric vehicle batteries, they are likely to eventually come in contact with cell membranes, with biological consequences that are currently not known. Here, we present nonlinear optical studies showing that lithium nickel manganese cobalt oxide nanosheets carrying a negative 味-potential have no discernible consequences for lipid alignment and interleaflet composition in supported lipid bilayers formed from zwitterionic and negatively charged lipids. In contrast, lithiated and delithiated LiCoO₂ nanosheets having positive and neutral 味-potentials, respectively, alter the compositional asymmetry of the two membrane leaflets, and bilayer asymmetry remains disturbed even after rinsing. The insight that some cobalt oxide nanoformulations induce alterations to the compositional asymmetry in idealized model membranes may represent an important step toward assessing the biological consequences of their predicted widespread use.