Cyclometalated Complexes of Platinum and Palladium with N-(4-Chlorophenyl)--benzoylbenzylideneamine. In Vitro Cytostat
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- 作者：Carmen Navarro-Ranninger ; Isabel Ló ; pez-Solera ; Ví ; ctor M. Gonzá ; lez ; José ; M. Pé ; rez ; Amparo Alvarez-Valdé ; s ; Avelino Martí ; n ; Paul R. Raithby ; José ; R
- 刊名：Inorganic Chemistry
- 出版年：1996
- 出版时间：August 28, 1996
- 年：1996
- 卷：35
- 期：18
- 页码：5181 - 5187
- 全文大小：233K
- 年卷期：v.35,no.18(August 28, 1996)
- ISSN：1520-510X
文摘
In the present paper we report the synthesis and structural IR and1H and 13C NMR characterization offourplatinum(II) and palladium(II) cyclometalated complexes ofthe formula[Pd(4-ClC6H4N=C(COC6H5)C6H4)X]2,where X = OAc (2) or Cl (3), and[Pt(4-ClC6H4N=C(COC6H5)C6H4)X]2,where X = Cl (4) or OAc (5).Theacetate-bridged compounds 2 and 5 have anopen-book structure. The chloro-bridged compounds 3 and4 havean unfolded structure. Complex 2 crystallizes in thecentrosymmetric triclinic space group P
, withZ = 2. Unitcell parameters are as follows: a = 11.765(3) Å,b = 12.862(4) Å, c = 15.022(5) Å,
= 84.08(2)
, 
= 78.56(2), 
= 83.13(2). All these compounds were screenedagainst MDA-MB 468 (breast carcinoma) and HL-60(leukemic) tumor cells. The low IC50 values ofcompound 5 (1.05 
M) and of compound 4 (1.58M) againstMDA-MB 468 and of 0.82 M (5) and 1.37 M (4)against HL-60 relative to cis-DDP (2.67 and 2.07M,respectively) and other cyclometalated compounds suggest that thesynthesized compounds may be regarded ashaving potential antitumor properties. The data suggest that theantiproliferative activity of compound 5 maycorrelate with its covalent binding to DNA and the induction ofimportant modifications on the helix.
, withZ = 2. Unitcell parameters are as follows: a = 11.765(3) Å,b = 12.862(4) Å, c = 15.022(5) Å, = 84.08(2), = 78.56(2), = 83.13(2). All these compounds were screenedagainst MDA-MB 468 (breast carcinoma) and HL-60(leukemic) tumor cells. The low IC50 values ofcompound 5 (1.05 M) and of compound 4 (1.58M) againstMDA-MB 468 and of 0.82 M (5) and 1.37 M (4)against HL-60 relative to cis-DDP (2.67 and 2.07M,respectively) and other cyclometalated compounds suggest that thesynthesized compounds may be regarded ashaving potential antitumor properties. The data suggest that theantiproliferative activity of compound 5 maycorrelate with its covalent binding to DNA and the induction ofimportant modifications on the helix.