Binding of Cationic Single-Chain and Dimeric Surfactants to Bovine Serum Albumin

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• 作者：Victoria Isabel Mart铆n ; Amalia Rodr铆guez ; Alfredo Maestre ; Mar铆a Luisa Moy谩
• 刊名：Langmuir
• 出版年：2013
• 出版时间：June 25, 2013
• 年：2013
• 卷：29
• 期：25
• 页码：7629-7641
• 全文大小：907K
• 年卷期：v.29,no.25(June 25, 2013)
• ISSN：1520-5827

文摘

The interactions between bovine serum albumin (BSA) and the single-chain surfactants N-benzyl-N,N-dimethyl-N-(1-dodecyl)ammonium bromide (PH12) and N-cyclohexylmethyl-N,N-dimethyl-N-(1-dodecyl)ammonium bromide (CH12) and their two dimeric counterparts, N,N鈥?[1,3-phenylenebis(methylene)]bis[N,N-dimethyl-N-(1-dodecyl)]ammonium dibromide (12PH12) and N,N鈥?[cyclohexane-1,3-diylbis(methylene)]bis[N,N-dimethyl-N-(1-dodecyl)]ammonium dibromide (12CH12), respectively, have been investigated by surface tension, fluorescence, circular dichroism, 味 potential, and atomic force microscopy. The results obtained permit the examination of the way an increase in the number of hydrophobic chains and the substitution of a cyclohexyl ring by a phenyl ring, either in the headgroup of single-chain surfactants or in the spacer of dimeric surfactants, affect BSA鈥搒urfactant interactions. The comparison of the fluorescence results with those obtained by 味 potential measurements shows that the sites of binding of the surfactants with aromatic rings to the BSA are somewhat different from those of the surfactants with no aromatic rings.