A Short-Cut Method for the Quantification of Crystallization Kinetics. 2. Experimental Application

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• 作者：Erik Temmel ; Matthias Eicke ; Heike Lorenz ; Andreas Seidel-Morgenstern
• 刊名：Crystal Growth & Design
• 出版年：2016
• 出版时间：December 7, 2016
• 年：2016
• 卷：16
• 期：12
• 页码：6756-6768
• 全文大小：745K
• ISSN：1528-7505

文摘

For the design of crystallization processes, the specific substances have to be characterized in terms of their thermodynamic properties but also with respect to the corresponding crystallization kinetics. In an accompanying theoretical study, a short-cut method was suggested and demonstrated for the quantification of different kinetic mechanisms, i.e., growth, dissolution, and nucleation. Here, this method will be utilized for the estimation of parameters comprised in kinetic submodels for three different substances. The experimental procedures as well as the data analysis will be discussed, and the quality of the parameter estimates will be evaluated by comparing predictions of a population balance model using the identified parameters with the results of corresponding validation experiments.