Jatrophane Diterpenes from Euphorbia esula as Antiproliferative Agents and Potent Chemosensitizers to Overcome Multidrug Resistance
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- 作者：Andrea Vasas ; Edva虂rd Sulyok ; Do虂ra Re虂dei ; Peter Forgo ; Pa虂l Szabo虂 ; Istva虂n Zupko虂 ; A虂gnes Bere虂nyi ; Joseph Molna虂r ; Judit Hohmann
- 刊名：Journal of Natural Products
- 出版年：2011
- 出版时间：June 24, 2011
- 年：2011
- 卷：74
- 期：6
- 页码：1453-1461
- 全文大小：841K
- 年卷期：v.74,no.6(June 24, 2011)
- ISSN：1520-6025
文摘
Phytochemical study of whole, undried plants of Euphorbia esula led to the isolation of six new (1鈥?b>6) jatrophane diterpene polyesters, named esulatins H鈥揗, together with the known compounds 2伪,3尾,5伪,7尾,15尾-pentaacetoxy-9伪-nicotinoyloxyjatropha-6(17),11-dien-14-one (7), salicinolide (8), and euphosalicin (9). The structures and relative configuration of 1鈥?b>6 were established on the basis of extensive spectroscopic analysis, including HRESIMS and one- and two-dimensional NMR techniques. All these compounds, together with diterpenes (10鈥?b>14) isolated previously from this plant, were evaluated for their antiproliferative activity against HeLa, Ishikawa, and MCF7 cells. The multidrug-resistance-reversing activities were also investigated on L5178 mouse lymphoma cells transfected with the pHa MDR1/A retrovirus DNA. Preliminary structure鈥揳ctivity relationship data are discussed.