Morphologies in Solvent-Annealed Clotrimazole Thin Films Explained by Hansen-Solubility Parameters

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• 作者：Heike M. A. Ehmann ; Andreas Zimmer ; Eva Roblegg ; Oliver Werzer
• 刊名：Crystal Growth & Design
• 出版年：2014
• 出版时间：March 5, 2014
• 年：2014
• 卷：14
• 期：3
• 页码：1386-1391
• 全文大小：318K
• 年卷期：v.14,no.3(March 5, 2014)
• ISSN：1528-7505

文摘

The induction of different crystal morphologies is of crucial importance for many applications. In this work, the preparation of various crystal morphologies within clotrimazole films on glass substrates is demonstrated. Amorphous clotrimazole thin films were transformed via vapor annealing into crystalline structures; highly monodisperse/multidisperse crystallites, spherulite, or dendritic structures were obtained as the solvent was exchanged. X-ray diffraction experiments reveal that the same polymorph is present for all samples but with varying texture. The achieved morphologies are explained in terms of Hansen-solubility parameters and vapor pressures; thus, the different morphologies and crystal orientations can be explained by solvent鈥攕olid interaction strengths within the thin film samples.