Titanocene-Based Method for Indole Synthesis
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- 作者：Kazumasa Aoki ; Andrew J. Peat ; and Stephen L. Buchwald
- 刊名：Journal of the American Chemical Society
- 出版年：1998
- 出版时间：April 8, 1998
- 年：1998
- 卷：120
- 期：13
- 页码：3068 - 3073
- 全文大小：246K
- 年卷期：v.120,no.13(April 8, 1998)
- ISSN：1520-5126
文摘
A new approach for the construction of indoles employing the air-and moisture-stable reagentCp2TiCl2 is described. The key stepsinvolved are (1) the intermolecular insertion reactions of an olefinanda titanocene-stabilized benzyne complex and (2) the Pd-catalyzed arylamination reaction. The simplicity andavailability of the requisite starting materials give the method abroad scope for the preparation of polysubstitutedindoles.