A Tandem Aza-Claisen Rearrangement and Ring Closing Metathesis Reaction for the Synthesis of Cyclic Allylic Trichloroacetamides

详细信息    查看全文

• 作者：Michael D. Swift ; Andrew Sutherland
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：December 6, 2007
• 年：2007
• 卷：9
• 期：25
• 页码：5239 - 5242
• 全文大小：68K
• 年卷期：v.9,no.25(December 6, 2007)
• ISSN：1523-7052

文摘

A one-pot tandem palladium(II)-catalyzed aza-Claisen rearrangement and ring closing metathesis process has been developed for the efficientsynthesis of cyclic allylic trichloroacetamides. The use of chiral Pd(II) catalysts such as (S)-COP-Cl during the rearrangement stage resultsin the preparation of these compounds in excellent yields and in high enantiomeric excess.