Triply Triggered Doxorubicin Release From Supramolecular Nanocontainers

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• 作者：Xian Jun Loh ; Jes煤s del Barrio ; Pearl Pei Chern Toh ; Tung-Chun Lee ; Dezhi Jiao ; Urs Rauwald ; Eric A. Appel ; Oren A. Scherman
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：January 9, 2012
• 年：2012
• 卷：13
• 期：1
• 页码：84-91
• 全文大小：480K
• 年卷期：v.13,no.1(January 9, 2012)
• ISSN：1526-4602

文摘

The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAEMA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli-responsive DHBC micelle system represents an evolution over conventional double stimuli-responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.