Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix
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- 作者：Mathumai Kanapathipillai ; Akiko Mammoto ; Tadanori Mammoto ; Joo H. Kang ; Elisabeth Jiang ; Kaustabh Ghosh ; Netanel Korin ; Ashley Gibbs ; Robert Mannix ; Donald E. Ingber
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：June 13, 2012
- 年：2012
- 卷：12
- 期：6
- 页码：3213-3217
- 全文大小：325K
- 年卷期：v.12,no.6(June 13, 2012)
- ISSN：1530-6992
文摘
A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(d,l-lactide-co-glycolide) nanoparticles (220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects.