Reversible Vesicle-to-Disk Transitions of Liposomes Induced by the Self-Assembly of Water-Soluble Porphyrins

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• 作者：Kouta SugikawaYutaro Takamatsu ; Kazuma Yasuhara ; Masafumi Ueda ; Atsushi Ikeda
• 刊名：Langmuir
• 出版年：2017
• 出版时间：January 31, 2017
• 年：2017
• 卷：33
• 期：4
• 页码：1023-1029
• 全文大小：526K
• ISSN：1520-5827

文摘

Structural control of lipid membranes is important for mechanisms underlying biological functions and for creating high-functionality soft materials. We demonstrate the reversible control of vesicle structures (liposomes) using supramolecular assemblies. Specifically, water-soluble anionic porphyrin molecules interact with positively charged lipid membrane surfaces to form one-dimensional self-assembled structures (J-aggregates) under acidic conditions. Cryogenic transmission electron microscopy revealed that porphyrin J-aggregates on the membrane surface induced an extensive structural change from vesicles to layered disks. Neutralization of the solution deformed the porphyrin J-aggregates, thereby reforming nanosized liposomes from the layered disks.