Atheroprotective Effects of Bilberry Extracts in Apo E-Deficient Mice

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• 作者：Aurelie Mauray ; Dragan Milenkovic ; Catherine Besson ; Nelly Caccia ; Christine Morand ; Francoise Michel ; Andrzej Mazur ; Augustin Scalbert ; Catherine Felgines
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：December 9, 2009
• 年：2009
• 卷：57
• 期：23
• 页码：11106-11111
• 全文大小：731K
• 年卷期：v.57,no.23(December 9, 2009)
• ISSN：1520-5118

文摘

Previous studies have demonstrated that the intake of berry foods was associated with a reduced risk of cardiovascular diseases. The aim of the present study was to evaluate the effects of two bilberry extracts, one rich in anthocyanins extracted from untreated bilberries (BE) and a second one extracted from yeast-fermented bilberries (FBE), on the development of atherosclerosis in apolipoprotein E-deficient mice (apo E^−/−). Apo E^−/− mice received for 16 weeks a diet supplemented with 0.02% of either BE or FBE. Atherosclerotic plaque area was measured in the aortic sinus. Supplementation of the diet with both bilberry extracts led to a significant inhibition of plaque development, whereas no effect on oxidative stress parameters or lipid profiles could be observed, suggesting the implication of other mechanisms of action. In addition, a better protection was observed with FBE, suggesting that the fermentation generates new bioactive compounds more effective in attenuating progression of the atherosclerotic lesions.