Catanionic Vesicles Formed with Arginine-Based Surfactants and 1,2-Dipalmitoyl-sn-glycero-3-phosphate Monosodium Salt

详细信息    查看全文

• 作者：Neus Lozano ; Aurora Pinazo ; Camillo La Mesa ; Lourdes Perez ; Patrizia Andreozzi ; Ramon Pons
• 刊名：Journal of Physical Chemistry B
• 出版年：2009
• 出版时间：May 7, 2009
• 年：2009
• 卷：113
• 期：18
• 页码：6321-6327
• 全文大小：217K
• 年卷期：v.113,no.18(May 7, 2009)
• ISSN：1520-5207

文摘

We report on mixing an anionic diacyl phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphate monosodium salt, DPPA) with either monoacyl and diacyl arginine-based surfactants. These mixtures are part of the rich family of pseudo-triple-chain and pseudo-tetra-chain catanionic mixtures, respectively. Vesicle size and ζ-potential were measured at several mixing ratios. Additional information on counterion binding, vesicle size, and integrity was obtained from ion selective electrode and Cryo-TEM measurements. Addition of positively charged surfactants to DPPA results in an increase of vesicle size. However, ζ-potential shows different trends, depending on whether water or acid media are used as solvent. In the latter, ζ-potential values progressively approach 0 upon addition of amino acid based surfactants. In water, surprisingly, ζ-potential values become more negative. The results are discussed in terms of modifications in counterion binding and vesicle size.