Regio- and Stereoselective Synthesis of a Library of Bioactive Dispiro-Oxindolo/Acenaphthoquino Andrographolides via 1,3-Dipolar Cycloaddition Reaction Under Microwave Irradiation
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- 作者：Abhijit Hazra ; Yogesh P. Bharitkar ; Debanjana Chakraborty ; Susanta Kumar Mondal ; Nupur Singal ; Shyamal Mondal ; Arindam Maity ; Rupankar Paira ; Sukdeb Banerjee ; Nirup B. Mondal
- 刊名：ACS Combinatorial Science
- 出版年：2013
- 出版时间：January 14, 2013
- 年：2013
- 卷：15
- 期：1
- 页码：41-48
- 全文大小：393K
- 年卷期：v.15,no.1(January 14, 2013)
- ISSN：2156-8944
文摘
Dispiro-pyrrolidino/pyrrolizidino fused oxindoles/acenaphthoquinones have been derived from andrographolide via azomethine ylide cycloaddition to the conjugated double-bond under microwave (MW) irradiation. The reactions are chemo-, stereo-, and regioselective in nature. Change in amino acid from sarcosine/N-benzyl glycine to l-proline changes the regiochemistry. A representative library of 40 compounds along with in vitro anticancer evaluation is reported.