Investigation of the Hepatic Glucuronidation Pattern of the Fusarium Mycotoxin Deoxynivalenol in Various Species

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• 作者：Ronald Maul ; Benedikt Warth ; Jill-Sandra Kant ; Nils Helge Schebb ; Rudolf Krska ; Matthias Koch ; Michael Sulyok
• 刊名：Chemical Research in Toxicology
• 出版年：2012
• 出版时间：December 17, 2012
• 年：2012
• 卷：25
• 期：12
• 页码：2715-2717
• 全文大小：162K
• 年卷期：v.25,no.12(December 17, 2012)
• ISSN：1520-5010

文摘

Deoxynivalenol (DON) is one of the most abundant mycotoxins contaminating food and feed worldwide. Upon absorption, the major portion of the toxin is excreted by humans and animal species as glucuronide. However, consistent in vitro data on DON glucuronidation are lacking. In the present study, the metabolism of DON was investigated using liver microsomes from humans and six different animal species. It was shown that all animal and human liver microsomes led to the formation of up to three different mono-O-glucuronides with significant interspecies differences. While the activity of human liver microsomes was low (0.8 to 2.2 pmol路min^鈥?路mg^鈥?), bovine liver and rat liver microsomes conjugated DON with activities of 525 pmol路min^鈥?路mg^鈥? and 80 pmol路min^鈥?路mg^鈥?, respectively.