One-Step Synthesis of Sulfonamides from N-Tosylhydrazones
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- 作者：Andy S. Tsai ; John M. Curto ; Benjamin N. Rocke ; Anne-Marie R. Dechert-Schmitt ; Gajendrasingh K. Ingle ; Vincent Mascitti
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：February 5, 2016
- 年：2016
- 卷：18
- 期：3
- 页码：508-511
- 全文大小：395K
- ISSN：1523-7052
文摘
The first described reaction between N-tosylhydrazone and SO2 is reported to provide alkyl sulfonamides in the presence of various amines. In this procedurally simple method, hydrazones of both unsaturated aldehydes and ketones proceed in moderate to excellent yields. Primary and secondary aliphatic amines are accommodated in this reaction, which provides a novel route to sulfonamides.