Exposure of an Adult Population to Perfluorinated Substances Using Duplicate Diet Portions and Biomonitoring Data
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- 作者：Hermann Fromme ; Martin Schlummer ; Angela Mö ; ller ; Ludwig Gruber ; Gerd Wolz ; Jan Ungewiss ; Sigrun Bö ; hmer ; Wolfgang Dekant ; Richard Mayer ; Bernhard Liebl ; Dorothee Twardella
- 刊名：Environmental Science & Technology
- 出版年：2007
- 出版时间：November 15, 2007
- 年：2007
- 卷：41
- 期：22
- 页码：7928 - 7933
- 全文大小：124K
- 年卷期：v.41,no.22(November 15, 2007)
- ISSN：1520-5851
文摘
Because dietary intake is supposed to be an importantroute of human exposure we quantified the dietary intakeof perfluorooctane sulfonate (PFOS), perfluorooctanoate(PFOA), perfluorohexane sulfonate (PFHxS), perfluorohexanoate (PFHxA), and perfluorooctane sulfonamide (PFOSA)using 214 duplicate diet samples. The study was carriedout with a study population of 15 female and 16 male healthysubjects aged 16-45 years. The participants collecteddaily duplicate diet samples over seven consecutive daysin 2005. Duplicate samples were homogenized and theirultrasonic extracts were cleaned up by SPE and subjectedto HPLC-ESI-MS/MS. In addition, individual intakes wereestimated based on blood levels of PFOS and PFOA usinga pharmacokinetic model. Blood samples were collectedonce during the sampling period. The median (90th percentile)daily dietary intake of PFOS and PFOA was 1.4 ng/kgb.w. (3.8 ng/kg b.w.) and 2.9 ng/kg b.w. (8.4 ng/kg b.w.),respectively. PFHxS and PFHxA could be detected only insome samples above detection limit with median(maximum) daily intakes of 2.0 ng/kg b.w. (4.0 ng/kg b.w.)and 4.3 ng/kg b.w. (9.2 ng/kg b.w.), respectively. BecausePFOSA could not be detected above the limit of detectionof 0.2 ng/g f.w. this indirect route of exposure seems tobe of less significance. Overall, the results of this studydemonstrate that the German population is exposed to PFOSand PFOA, but the median dietary intake did not reachthe recommended tolerable daily intake by far. Biomonitoringdata predict an exposure in a comparable range. Wesuppose that, normally, food intake is the main source ofexposure of the general population to PFOS and PFOA.