Hispidin Analogue Davallialactone Attenuates Carbon Tetrachloride-Induced Hepatotoxicity in Mice

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• 作者：Prabodh Risal ; Pyoung Han Hwang ; Bong Sik Yun ; Ho-Keun Yi ; Baik Hwan Cho ; Kyu Yun Jang ; Yeon Jun Jeong
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：October 26, 2012
• 年：2012
• 卷：75
• 期：10
• 页码：1683-1689
• 全文大小：477K
• 年卷期：v.75,no.10(October 26, 2012)
• ISSN：1520-6025

文摘

In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄)-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection (1 mg/kg). Protection from liver injury by 1 was confirmed by the observation of decreased serum transaminases and diminished necrosis of liver tissue. Reduced hepatic injury was very similar to that observed with silymarin, a known hepatoprotective drug used in this work for comparison. The groups treated with 1 had reduced reactive oxygen species (ROS), reduced serum malonyldialdehyde levels, and increased levels of liver Cu/Zn superoxide dismutase, as compared to the CCl₄ control group. The expression of heme oxygenase-1 in the liver tissue was increased and the activity of liver cytochrome P4502E1 was restored in the mice treated with 1. In addition, levels of serum tumor necrosis factor-alpha (TNF-伪), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2), numbers of macrophage, and cleaved caspase-3-positive hepatocytes were reduced in the groups treated with 1. These findings suggest that davallialactone has protective effects against CCl₄-induced acute liver injury, and this protection is likely due to the suppression of ROS-induced lipid peroxidation and inflammatory response.