Application of 3D NMR for Structure Determination of Peptide Natural Products
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- 作者：Fan Zhang ; Navid Adnani ; Emmanuel Vazquez-Rivera ; Doug R. Braun ; Marco Tonelli ; David R. Andes ; Tim S. Bugni
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：September 4, 2015
- 年：2015
- 卷：80
- 期：17
- 页码：8713-8719
- 全文大小：394K
- ISSN：1520-6904
文摘
Despite the advances in NMR, structure determination is often slow and constitutes a bottleneck in natural products discovery. Removal of this bottleneck would greatly improve the throughput for antibiotic discovery as well as other therapeutic areas. Overall, faster structure methods for structure determination will serve the natural products community in a broad manner. This report describes the first application of 3D NMR for elucidation of two microbially produced peptide natural products with novel structures. The methods are cost-effective and greatly improve the confidence in a proposed structure.