Periodic Macroporous Hydroxyapatite-Containing Calcium Phosphates
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- 作者：Brian J. Melde and Andreas Stein
- 刊名：Chemistry of Materials
- 出版年：2002
- 出版时间：August 2002
- 年：2002
- 卷：14
- 期：8
- 页码：3326 - 3331
- 全文大小：239K
- 年卷期：v.14,no.8(August 2002)
- ISSN：1520-5002
文摘
Three-dimensionally ordered macroporous materials containing the bioceramic hydroxyapatite as well as other calcium phosphate and carbonate phases have been synthesizedusing close-packed poly(methyl methacrylate) latex spheres (256-375 nm diameter) astemplates. The interstitial spaces of the colloidal crystal were penetrated by a water/alcoholcosolvent solution of calcium nitrate and phosphoric acid. Calcination in the range 475-1000 
C removed the polymer and promoted crystallization of calcium phosphate phases inthe pore walls. The materials were characterized by powder X-ray diffraction, FT-IRspectroscopy, and SEM. The best combination of composition and three-dimensional orderwas found in a crystalline hydroxyapatite/tricalcium phosphate templated with 375-nmspheres and calcined at 700 C. An in vitro antibiotic drug release application was testedusing this product.
C removed the polymer and promoted crystallization of calcium phosphate phases inthe pore walls. The materials were characterized by powder X-ray diffraction, FT-IRspectroscopy, and SEM. The best combination of composition and three-dimensional orderwas found in a crystalline hydroxyapatite/tricalcium phosphate templated with 375-nmspheres and calcined at 700 C. An in vitro antibiotic drug release application was testedusing this product.