Ferruginenes A鈭扖 from Rhododendron ferrugineum and Their Cytotoxic Evaluation

详细信息    查看全文

• 作者：Prapairat Seephonkai ; Ruxandra Popescu ; Martin Zehl ; Georg Krupitza ; Ernst Urban ; Brigitte Kopp
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：April 25, 2011
• 年：2011
• 卷：74
• 期：4
• 页码：712-717
• 全文大小：815K
• 年卷期：v.74,no.4(April 25, 2011)
• ISSN：1520-6025

文摘

Three new compounds, ferruginenes A (1) and B (2) and a mixture of C-5鈥?R) and C-5鈥?S) ferruginene C (3) diastereomers, have been isolated from a cytotoxic chloroform-soluble fraction of the leaves of Rhododendron ferrugineum together with 12 known compounds. The structures of these new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometric data. Compounds 1鈭?b>3 were tested for their cytotoxicity against three human cancer cell lines, namely, HL-60, HeLa-S3, and MCF-7.