Antimalarial Benzylisoquinoline Alkaloid from the Rainforest Tree Doryphora sassafras

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• 作者：Malcolm S. Buchanan ; Rohan A. Davis ; Sandra Duffy ; Vicky M. Avery ; Ronald J. Quinn
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：August 28, 2009
• 年：2009
• 卷：72
• 期：8
• 页码：1541-1543
• 全文大小：86K
• 年卷期：v.72,no.8(August 28, 2009)
• ISSN：1520-6025

文摘

Mass-directed isolation of the CH<sub>2sub>Cl<sub>2sub>/MeOH extract of Doryphora sassafras resulted in the purification of a new benzylisoquinoline alkaloid, 1-(4-hydroxybenzyl)-6,7-methylenedioxy-2-methylisoquinolinium trifluoroacetate (1), and the known aporphine alkaloid (S)-isocorydine (2). The structures of 1 and 2 were determined by 1D and 2D NMR and MS data analyses. The compounds were isolated during a drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library. When tested against two different strains of the parasite Plasmodium falciparum (3D7 and Dd2), 1 displayed IC<sub>50sub> values of 3.0 and 4.4 μM, respectively. Compound 1 was tested for cytotoxicity toward a human embryonic kidney cell line (HEK293) and displayed no activity at 120 μM.