Flinderoles A−C: Antimalarial Bis-indole Alkaloids from Flindersia Species

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• 作者：Liza S. Fernandez ; Malcolm S. Buchanan ; Anthony R. Carroll ; Yun Jiang Feng ; Ronald J. Quinn ; Vicky M. Avery
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：January 15, 2009
• 年：2009
• 卷：11
• 期：2
• 页码：329-332
• 全文大小：130K
• 年卷期：v.11,no.2(January 15, 2009)
• ISSN：1523-7052

文摘

With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A−C were found to have selective antimalarial activities with IC<sub>50sub> values between 0.15−1.42 μM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A−C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.