Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications
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- 作者：Sabyasachi Chakrabortty ; Bikram Keshari Agrawalla ; Anne Stumper ; Naidu M Vegi ; Stephan Fischer ; Christian Reichardt ; Michael Kögler ; Benjamin Dietzek ; Michaela Feuring-Buske ; Christian Buske ; Sven Rau ; Tanja Weil
- 刊名：Journal of the American Chemical Society
- 出版年：2017
- 出版时间：February 15, 2017
- 年：2017
- 卷：139
- 期：6
- 页码：2512-2519
- 全文大小：524K
- ISSN：1520-5126
文摘
Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity toward several cancerous cell lines. In particular, enhanced anticancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs. Finally, attractive two-photon absorbing properties further underlined the great significance of this PS for mitochondria targeted PDT applications in deep tissue cancer therapy.