New Gadolinium Complex with Efficient Hydrolase-like Activity: A 100-Million-Fold Rate Enhancement in Diester Hydrolysis

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• 作者：Maryene A. Camargo ; Ademir Neves ; Adailton J. Bortoluzzi ; Bruno Szpoganicz ; Adriano Martendal ; Michael Murgu ; Franciele L. Fischer ; Herná ; n Terenzi ; Patricia Cardoso Severino
• 刊名：Inorganic Chemistry
• 出版年：2008
• 出版时间：April 21, 2008
• 年：2008
• 卷：47
• 期：8
• 页码：2919 - 2921
• 全文大小：288K
• 年卷期：v.47,no.8(April 21, 2008)
• ISSN：1520-510X

文摘

The synthesis, structure, and hydrolase-like catalytic activity of a new mononuclear gadolinium complex [Gd(L)(NO₃)(H₂O)₃](NO₃)₂ (1) are reported. A clean two-stage kinetic reaction for hydrolysis of the diester 2,4-bis(dinitrophenyl)phosphate by 1 was followed, and the rate constants were determined. A high DNA cleavage activity was also demonstrated. The active species in the hydrolytic process is proposed based on the X-ray structure, electrospray ionization mass spectrometry analysis, and kinetic and potentiometric equilibrium studies of 1.